View abstract. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. Rembold, C. M. and Chen, X. L. Mechanisms responsible for forskolin-induced relaxation of rat tail artery. - Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Umali Stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. Zeng, S., Shen, B., Wen, L., Hu, B., Peng, D., Chen, X., and Zhou, W. Experimental studies of the effect of Forskolin on the lowering of intraocular pressure. Coleus species are native to tropical and subtropical regions of Africa, Australia, the East Indies, the Malay Archipelago, and the Philippines. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Surgery: Forskolin, a chemical found in coleus, might increase bleeding during and after surgery. This could show us how to manipulate these cultures in a direction where secondary compound production starts. 1998;93 Suppl 1:66-75. When taken by mouth, coleus is used to treat allergies , dry eye, skin conditions such as eczema and psoriasis , obesity , painful menstrual periods, irritable bowel syndrome ( IBS ), urinary tract infections ( UTI ), bladder infections, advanced cancer , blood clots , sexual problems in men, trouble sleeping ( insomnia ), and convulsions . A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Therefore, large amounts of rosmarinic acid could be produced by in vitro cultures; however, a market for rosmarinic acid does not exist at the moment, and the commercial value of this compound is therefore low. Asia Pac J Clin Nutr 2006;15(2):267-274. Vasa 1990;19(4):315-319. Yokotani K, Chiba T, Sato Y, et al. The upper lip is often two-lobed, the lower longer, often three-lobed, and frequently contains the two pairs of deflexed stamens and style. Sashidhara, K. V., Rosaiah, J. N., Kumar, A., Bid, H. K., Konwar, R., and Chattopadhyay, N. Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro. Cell Biol Int 2006;30(11):940-946. Meyer BH, Stulting AA, Muller FO, et al. View abstract. Biochem Pharmacol 1-1-1987;36(1):13-20. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. Seed and seed rate Acta Cir.Bras. Huerta M, Urzúa Z, Trujillo X, et al. J Asian Nat Prod Res 2006;8(4):355-360. Clinical efficacy of Coleus forskohlii (Willd.) Cell cultures of C. blumei accumulate up to 21% of the cell dry weight as rosmarinic acid, which is one of the highest accumulation levels of secondary products in plant cell cultures ever found, compared to 2-3% in the plant. Lancet 1983;1:958-60. Today, more soluble semi-synthetic derivatives are produced with plant-derived forskolin as basic molecule and used for clinical studies in Japan for treatment of cardiac disorders. Nevertheless, numerous publications on this species use the name C. blumei, namely, reports on the production of rosmarinic acid by this species. Forskolin is a chemical found in the roots of the coleus plant. Li, Z. and Wang, J. View abstract. Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. Set plants out after all danger of frost is past. Therefore, the legitimate name for the plant is Coleus scutellarioides (L.) Bentham. However, currently there is no reliable scientific information that shows Coleus extracts taken by mouth are effective. View abstract. View abstract. Shen, Y. H. and Xu, Y. L. Two new diterpenoids from Coleus forskohlii. Caprioli J, Sears M. Forskolin lowers intraocular pressure in rabbits, monkeys, and man. Heart disease: Forskolin, a chemical found in coleus, might lower blood pressure. View abstract. The compound is able to lower hypertension by decreasing the peripheral resistance, and it also has a positive inotropic effect on the heart muscle. It has been used in traditional Ayurvedic medicine for curing various disorders and this is the only source of the diterpenoid forskolin. If the production of forskolin by cell or organ cultures could be further optimized, these in vitro cultures might become a further source for forskolin besides field-grown plants. They have square stems, opposite, toothed, stalked, or stalkless leaves and asymmetrical flowers. Therefore, it may be used to treat congestive heart failure. Invest Ophthalmol Vis Sci 1984;25:268-77. The health benefits of Mayana Leaves, also known as Coleus. Since the acute toxicity of forskolin is much lower than the therapeutic range, this compound or semi-synthetic derivatives may be promising drugs of the future. A high amount of rosmarinic acid is accumulated in only a few days at the end of the growth phase of the cell cultures. Vetrugno M, Uva MG, Russo V, et al. These preparations are being promoted for the same conditions for which forskolin has been traditionally used. Forskolin has a number of promising pharmacological effects and has become an important research tool since its discovery. J Int Med Res. Acta Diabetol Lat 1991;28(1):71-77. The only style has two stigmas. The appropriate dose of coleus depends on several factors such as the user's age, health, and several other conditions. View abstract. Bartels, S. P., Lee, S. R., and Neufeld, A. H. The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits. Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. J Cardiovasc.Pharmacol 1992;19(5):779-789. Preparations from several Coleus species are used in Ayurvedic medicine in India, e.g., preparations from C. amboinicus are active against skin problems and worms. Acta Endocrinol (Copenh) 1985;108(3):367-371. 2016 Apr;32(3):178-83. View abstract. View abstract. Eur.J Vasc.Surg 1991;5(3):271-275. When taken by mouth, coleus is used to treat allergies, dry eye, skin conditions such as eczema and psoriasis, obesity, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infections (UTI), bladder infections, advanced cancer, blood clots, sexual problems in men, trouble sleeping (insomnia), and convulsions. Certain varieties with striking foliage can only be propagated by cuttings that can be easily rooted. Bersudsky, Y., Kotler, M., Shifrin, M., and Belmaker, R. H. A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. 1996;103(12):1463-1467. It is used as a medicinal plant in India, Indonesia, and Mexico. Medicinal use was mapped to the Paton et al. However, RA-producing cell cultures of C. blumei have become a useful system for basic research concerning the regulation of secondary product biosysnthesis. 2005;13(8):1335-43. It is used as a medicinal plant in India, Indonesia, and Mexico. This plant is native to areas in the lower elevations of India. (2004) phylogenetic analysis. Other varieties are reproduced by seeds. Also clinical studies have been performed with forskolin and semisynthetic derivatives of this compound and are still being published numerously. Members of the genus Coleus produce interesting secondary compounds from very different classes, e.g., C. blumei synthesizes rosmarinic acid and C. forskohlii forskolin, which belong to the caffeic acid esters and the diterpenoids respectively. J Ocul Pharmacol Ther. View abstract. Stay on the safe side and avoid use. Coleus is POSSIBLY SAFE for most adults when taken by mouth, given intravenously (by IV), when inhaled (breathed in), or when applied as eye drops. Int J Cancer 1983;32:801-4. Bentham (1832-1836) considered these two plants as different species and placed them into the genus Coleus, with the names C. blumei and C. scutellarioides. Bleeding disorders: There is some evidence that forskolin, a chemical found in coleus, might increase the risk of bleeding in some people. View abstract. View abstract. Don't use coleus if you are taking medications that increase blood flow to the heart.. González-Sánchez R, Trujillo X, Trujillo-Hernández B, et al. Ayu. Mulhall, J. P., Daller, M., Traish, A. M., Gupta, S., Park, K., Salimpour, P., Payton, T. R., Krane, R. J., and Goldstein, I. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy. View abstract. View abstract. [Studies on the chemical constituents in root of Coleus forskohlii]. This is not the rule, since a number of secondary compounds of higher plants are not produced in cell cultures at all or only in very low concentrations. Basic Res Cardiol. View abstract. Thromb Haemost 1989;61:106-10. is an important medicinal plant native to India. Planta Med 1985;6:473-7. 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